史培良
基本情况
姓名:史培良 |
性别:男 |
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工作单位:成都药康生物科技有限公司 |
职称:副高 |
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学位:博士 |
学历:博士研究生 |
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毕业院校:南京大学 |
邮箱:shipl@gempharmatech.com |
个人简介:
史培良博士具有十余年固有免疫代谢研究经验,在基因工程疾病动物模型领域具有丰富的理论知识和市场转化能力。2016年进入南京大学医学院模式动物研究所任博士后研究员,后任江苏集萃药康生物科技股份有限公司市场总监。2018年起,参与成都药康生物科技有限公司筹备设立,并任总经理兼技术总支持,负责公司的组织搭建、基础建设、投产运营等,2020年至今陆续入选了四川地区的省、市高层次人才专家,以及温江区人才大使。
学术成果
(1) 大、小鼠疾病模型的产业化研发平台的建立 (2) Gsdma3自我调控机制及诱导细胞死亡机制研究 (3) GSDM家族基因在焦亡及炎症性疾病机制研究 (4) 集萃药康“斑点鼠”计划项目 (5) 一种CD38基因人源化实验动物模型的构建及应用 (6) 基于新靶点的重大传染病人源化动物模型研发 2. 代表性学术论文 (1) The stem cell factor/Kit signalling pathway regulates mitochondrial function and energy expenditure (2) Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy (3) Loss of conserved Gsdma3 self-regulation causes autophagy and cell death (4) Anti-mouse CD52 monoclonal antibody ameliorates intestinal epithelial barrier function in interleukin-10 knockout mice with spontaneous chronic colitis (5) Liver-specific deletion of Ppp2calpha enhances glucose metabolism and insulin sensitivity (6) Maresin 1 ameliorates iron-deficient anemia in IL-10(-/-) mice with spontaneous colitis by the inhibition of hepcidin expression though the IL-6/STAT3 pathway. (7) Dysregulated miR-98 Contributes to Extracellular Matrix Degradation by Targeting IL-6/STAT3 Signaling Pathway in Human Intervertebral Disc Degeneration (8) A Small Indel Mutant Mouse Model of Epidermolytic Palmoplantar Keratoderma and Its Application to Mutant-specific shRNA Therap (9) The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice (10) Cryptotanshinone, a novel tumor angiogenesis inhibitor, destabilizes tumor necrosis factor-alpha mRNA via decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR (11) PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte (12) Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14 (13) Dietary Non-digestible Polysaccharides Ameliorate Intestinal Epithelial Barrier Dysfunction in IL-10 Knockout Mic (14) GPR120, a potential therapeutic target for experimental colitis in IL-10 deficient mice (15) MicroRNA-218-5p as a Potential Target for the Treatment of Human Osteoarthritis (16) Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase (17) GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity (18) Anti-mouse CD52 Treatment Ameliorates Colitis through Suppressing Th1/17 Mediated Inflammation and Promoting Tregs Differentiation in IL-10 Deficient Mice 3. 代表性专著 无 4. 授权专利 (1) 一种条件性细胞死亡动物模型的构建方法及应用 (2) 一种实验动物微生物多重PCR快速检测试剂盒及快速检测方法 (3) 一种小鼠培养室用手套 (4) 一种小鼠用保温装置 (5) 一种小鼠安乐死装置 (6) 一种小鼠注射用固定器 (7) 一种小鼠模型培养室用防护服 (8) 一种小鼠固定装置 (9) 一种方便内部传输小鼠用笼盒 5.成果奖 无 |
其他工作
(1) 2020.11至今,四川农业大学,研究生校外导师
(2) 2022.12至今,四川大学,研究生产业导师
(3) 2023.09至今,成都医学院,硕士研究生指导教师
(4) 2023.09至今,四川省实验动物学会常务理事