姓名：任科

职称：副教授

1.科研项目

（1） 国家自然科学基金青年基金，“HSV-1利用宿主蛋白BRD4协助自身基因转录的分子机制研究”，31800154，2019/01-2021/12，负责人；

（2） 国家博士后科学基金，“JNK/BRD4调控HSV-1基因转录及潜伏感染/再激活的机制”，2021M693953，2021/05-2022/05，负责人；

（3） 国家留学基金委西部地区人才培养项目，202108515039，2022/12-2023/12；

（4） 四川省科技厅面上项目，“基于黑磷纳米片/功能化红细胞膜构建具备高效内涵体-溶酶体逃逸及脾靶向特性的仿生COIVD-19 mRNA疫苗”，2023NSFSC0127，2023/01-2024/12，负责人；

（5） 四川省科技厅科教联合项目，“靶向激活肿瘤相关巨噬细胞训练免疫增强胶质母细胞瘤放疗疗效及其机制研究”，2025NSFSC2139，2026/01-2027/12，负责人；

（6） 江苏省博士后科学基金，“ICP27活化JNK/p38诱导BRD4与染色质解离促进HSV-1基因转录的机制”，2021K385C，2021/06-2022/06，负责人；

（7） 成都医学院自然基金，“JNK活化致BRD4与宿主染色质解离在HSV-1基因转录调控中作用及机制”，CYZ18-01，2019/01-2021/12，负责人；

（8） 发育与再生四川省重点实验室开放基金，“小分子JQ1促HSV-1复制的分子机制及其与溶瘤HSV-1联用治疗皮肤黑色素瘤的研究”，SYS20-07，2020/01-2022/12，负责人；

（9） 四川养老与老年健康协同创新中心自然科学科研基金，“JNK-BRD4通路调控HSV-1基因转录的分子机制研究”，YLZBZ2002，2020/01-2022/12，负责人；

（10）成都医学院丽研工坊医美研究中心重点专项项目，“一氧化氮功能化的可注射复合水凝胶促进皮肤创伤修复的研究”，22YM002，2023/01-2024/12，负责人；

（11）成都医学院-成都市新都区人民医院联合科研基金，“基于黑磷纳米片构建多模式一体化靶向纳米药物通过重塑肿瘤微环境治疗脑胶质瘤”，2022LHXD-02，2023/01-2025/12，负责人；

（12）四川省中医药管理局自然科学面上项目，“基于网络药理学方法探究草果主要活性成分香叶醇通过调控EGFR/PI3K/AKT通路抑制炎症治疗溃疡性结肠炎的分子机制”，2024MS149，2023/06-2025/05，负责人；

（13）成都医学院“成医英才”登峰计划-青年人才培育项目，2024qnGzn13，2024/07/01-2027/06/30，负责人；

（14）成都医学院-四川生工创新科学研究股份有限公司，“甲供材料抗RSV感染小鼠体内药效评价”，2024（792），2025/06-2025/12，负责人；

2.科研论文（一作及通讯，含共同）

(1)Ke Ren^#,*, Ziyang Yuan^#, Lei Lei^#, Ziyuan Xiao, Ningyi Ma, Guodong Wang, Ningyi Sun, Tai Yang, Zhiyong Chang, Liang Qin, Ying Xu, Dahai Yu*, Lizhou Jia*, Haishi Qiao*. Engineered BCG selectively triggers trained immunity in tumor-associated macrophages and sensitizes glioblastoma to radiotherapy in mice.Nature Communications, 2026 Apr 20. doi: 10.1038/s41467-026-72067-7.

(IF: 15.7)

(2) Ziyuan Xiao^#, Huizhen Xu^#, Ningyi Ma^#, Lei Lei, Chunyu Cong, Ningyi Sun, Guodong Wang, Xingmei Chen*,Ke Ren*, Haishi Qiao*. A BCG hydrogel enables localized NOD2/STING activation to overcome resistance to immune checkpoint blockade.Proceedings of the National Academy of Sciences of the United States of America, 2026 May 26;123(21):e2531588123. doi: 10.1073/pnas.2531588123.(IF: 9.1)

(3) Yanqiang Huang^#, Lei Lei^#, Lingli Huang^#, Wanping Yang, Chunyu Cong, Huizhen Xu, Guodong Wang, Jiazi Luo, Wenting Zhou, Ningyi Sun, Yi He, Min Dai, Shuyu Zhang, Biaoliang Wu*, Haishi Qiao*,Ke Ren*.A biomimetic nanovesicle derived from BCG-primed macrophages with mannose modification for targeted immunotherapy against cryptococcal meningitis.Journal of Controlled Release,2026 Mar 10;391:114596. doi: 10.1016/j.jconrel.2025.114596.(IF: 10.8)

(4) Yanan Hu^#, Rong Li^#, Jiaxi Feng^#, Ningyi Sun, Wei Zheng, Xin Jin, Guodong Wang, Yi He, Yiwei Hao, Jun Zhang*,Ke Ren*, Xin Wu*.Pseudomonas aeruginosa induces tumor pyroptosis and immune activation to enhance checkpoint blockade in colorectal cancer.Cancer Immunology, Immunotherapy, 2026 Jan 3;75(1):32. doi: 10.1007/s00262-025-04266-y.(IF: 5.1)

(5) Yi Zhao, Zhengqun Dai, Yanmei Lang, Rui Li, Hongyu Zheng, Jiajia Mi, Xiu He, Jin Liu, Rong Xiang, Xueran Mei, Yang Liu, Yantang Wang, Huijie Guo, Qian Yang,Ke Ren*, Tai Yang*. Screening of Fecal Bacteroides Strains and Discovery of Bacteroides eggerthii S13‑F8 with Protective Effects Against Chemotherapy‑Induced Diarrhea.Probiotics and Antimicrobial Proteins, 2026 Jan;18(1):1003-1019. doi: 10.1007/s12602-025-10595-2.(IF: 5.0)

(6) Weikang Sun^#,Ke Ren^#, Jingjing Li^#, Mengyu Zhang, Qishen Jiang, Lingling Wang*, Erguang Li*. Activation of the stress-activated protein kinase JNK in response to herpes Simplex virus-1 infection coordinates transition of BRD4 from chromosome association totranscription elongation.Journal of Biological Chemistry, 2025 Sep;301(9):110590. doi: 10.1016/j.jbc.2025.110590.(IF: 3.9)

(7) Libo Zhang^#, Ziyuan Xiao^#, Dexin Zhang, Lixin Yang, Ziyang Yuan, Guodong Wang, Xue Rui, Qiang Fu, Yong Song*, Ke Ren* Haishi Qiao*. Targeted Initiation of Trained Immunity in Tumor Associated Macrophages with Membrane Camouflaged Bacillus Calmette-Guérin for Lung Carcinoma Immunotherapy.

ACS Nano. 2024 Dec 17;18(50):34219-34234. doi: 10.1021/acsnano.4c11658.(IF: 16.1)

(8) Dexin Zhang, Guodong Wang, Ningyi Ma, Ziyang Yuan, Yuqin Dong, Xin Huang, Haishi Qiao*,Ke Ren*. Biomedical Applications of Cell Membrane-Based Biomimetic Nano-Delivery System.Advanced Therapeutics,2024 Feb;7(2), 2300304. doi:10.1002/adtp.202300304. (IF: 4.6)

(9) Youqing Ye^#,Ke Ren^#, Yuqin Dong, Lixin Yang, Dexin Zhang, Ziyang Yuan,

Ningyi Ma, Yong Song* Xin Huang*, and Haishi Qiao*. Mitochondria-Targeting

Pyroptosis Amplifier of Lonidamine-Modified Black Phosphorus Nanosheets for

Glioblastoma Treatments.ACS Applied Materials & Interfaces, 2023 Jun

7;15(22):26285-26297. doi: 10.1021/acsami.3c01559.(IF: 9.5)

(10) Wei Guo^#,Ke Ren^#, Ruihong Ning^#, Caiwu Li^#, Yu Zhang, Yunong Gan, Xiaoyan

Fu, Cenjun Xiao, Yaoyu Pang, Lei Cheng, Siyuan Zhang, Desheng Li, Jiangchao Zhao*, Min Dai*, Ying Li*. Microbial species from multiple maternal body sites shape the developing giant panda (Ailuropoda melanoleuca) cub gut microbiome.Molecular Ecology, 2023 May;32(9):2271-2286. doi: 10.1111/mec.16869.

(IF: 6.7)

(11) Xin Huang^#,Ke Ren^#, Zhiyong Chang, Youqing Ye, Dechun Huang, Wei Zhao,

Lixin Yang, Yuqin Dong, Zhiting Cao*, Haishi Qiao*. Glucose Oxidase and

L-Arginine Functionalized Black Phosphorus Nanosheets for Multimodal Targeted

Therapy of Glioblastoma.Chemical Engineering Journal, 2022 Feb 15;430(2),

132898. doi:10.1016/j.cej.2021.132898. (IF: 16.7)

(12)Ke Ren^#, Jinghui Sun^#, Lingling Liu^#, Yuping Yang, Honghui Li, Zhichao Wang, Jingzhu Deng, Min Hou, Jia Qiu, Wei Zhao*. TP53-Activated lncRNA GHRLOS Regulates Cell Proliferation, Invasion, and Apoptosis of Non-Small Cell Lung Cancer by Modulating the miR-346/APC Axis.Frontiers in Oncology, 2021 Apr 21:11:676202. doi: 10.3389/fonc.2021.676202.(IF: 6.2)

(13) Wei Guo^#,Ke Ren^#, Ruihong Ning^#, Caiwu Li, Hemin Zhang, Desheng Li, Lin Xu, Fenghui Sun* and Min Dai*. Fecal microbiota transplantation provides new insight into wildlife conservation.Global Ecology and Conservation, 2020 Dec;24:e01234.(IF: 3.8)

(14)Ke Ren, Yuanzi Lv, Yujie Zhuo, Changmai Chen, Hengfei Shi, Lin Guo, Guang Yang, Yayi Hou, Ren Xiang Tan Erguang Li*. Suppression of IRG-1 Reduces Inflammatory Cell Infiltration and Lung Injury in Respiratory Syncytial Virus Infection by Reducing Production of Reactive Oxygen Species.Journal of Virology, 2016 Jul 27;90(16):7313-7322. doi: 10.1128/JVI.00563-16.(IF: 4.6)

(15)Ke Ren^#, Wei Zhang^#, Xiaoqing Chen, Yingyu Ma, Yue Dai, Yimei Fan, Yayi Hou, Ren Xiang Tan*, Erguang Li*. An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4. PLoS Pathogens, 2016 Oct 20;12(10):e1005950. doi: 10.1371/journal.ppat.1005950.(IF: 7.0)

(16) Hengfei Shi^#,Ke Ren^#, Baojie Lv, Baojie Lv, Wei Zhang, Ying Zhao, Ren Xiang Tan. Erguang Li*. Baicalin from Scutellaria baicalensis blocks respiratory syncytial virus (RSV) infection and reduces inflammatory cell infiltration and lung injury in mice. Scientific Report, 2016 Oct 21:6:35851. doi: 10.1038/srep35851.(IF: 5.2)

(17)Ke Ren, Chen Gao, Jin Zhang, Ke Wang, Yin Xu, Shao-Bin Wang, Hui Wang, Chan Tian, Qi Shi, Xiao-Ping Dong*. Flotillin-1 mediates PrP^Cendocytosis in the cultured cells during Cu²⁺stimulation through molecular interaction.Molecular Neurobiology, 2013 Dec;48(3):631-46. doi: 10.1007/s12035-013-8452-4.

(IF: 5.3)

3.授权专利

（1）一种促进单纯疱疹病毒复制的化合物及应用，2016.10.09，中国，专利号：201610906251.5；

（2）迷迭香酸在制备抑制水痘-带状疱疹病毒的药物中的用途，2019.10.25，中国，专利号：201910251925.6；

（3）草果在制备抗病毒药物中的新用途，201911.07，中国，专利号：201911083128.8；

（4）一种巨噬细胞膜包覆BCG的靶向生物制剂及其应用，2024.05.08，中国，申请号：202410559988.9

4.成果奖

（1）“中药防控细菌耐药性的关键技术与应用”四川省科技厅科技进步二等奖2021，参与人；

（2）“中药防控多重耐药病原菌传播与感染关键技术创新与应用”，中华医学科技三等奖，2022，参与人；