1.科研项目 （1） 国家自然科学基金青年基金，“HSV-1利用宿主蛋白BRD4协助自身基因转录的分子机制研究”，31800154，2019/01-2021/12，30万，负责人； （2） 国家博士后科学基金，“JNK/BRD4调控HSV-1基因转录及潜伏感染/再激活的机制”，2021M693953，2021/05-2022/05，8万，负责人； （3） 国家留学基金委西部地区人才培养项目，202108515039，2022/12-2023/12； （4） 四川省科技厅面上项目，“基于黑磷纳米片/功能化红细胞膜构建具备高效内涵体-溶酶体逃逸及脾靶向特性的仿生COIVD-19 mRNA疫苗”，2023NSFSC0127，2023/01-2024/12，20万，负责人； （5） 江苏省博士后科学基金，“ICP27活化JNK/p38诱导BRD4与染色质解离促进HSV-1基因转录的机制”，2021K385C，2021/06-2022/06，10万，负责人； （6） 成都医学院自然基金，“JNK活化致BRD4与宿主染色质解离在HSV-1基因转录调控中作用及机制”，CYZ18-01，2019/01-2021/12，5万，负责人； 2.科研论文 (1)Ke Ren, Chen Gao, Jin Zhang, Ke Wang, Yin Xu, Shao-Bin Wang, Hui Wang, Chan Tian, Qi Shi, Xiao-Ping Dong. Flotillin-1 mediates PrPC endocytosis in the cultured cells during Cu2+stimulation through molecular interaction.Molecular Neurobiology, 48(3):631-46, 2013. (IF:5.3) (2)Ke Ren, Wei Zhang, Xiaoqing Chen, Yingyu Ma, Yue Dai, Yimei Fan, Yayi Hou, Ren Xiang Tan, Erguang Li*. An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4. PLoS Pathogens, 12(10): e1005950, 2016. (IF: 7.0) (3)Ke Ren, Yuanzi Lv, Yujie Zhuo, Changmai Chen, Hengfei Shi, Lin Guo, Guang Yang, Yayi Hou, Ren Xiang Tan Erguang Li*. Suppression of IRG-1 Reduces Inflammatory Cell Infiltration and Lung Injury in Respiratory Syncytial Virus Infection by Reducing Production of Reactive Oxygen Species. Journal of Virology, 90(16):7313-22, 2016. (IF: 4.6) (4)Ke Ren, Jinghui Sun, Lingling Liu, Yuping Yang, Honghui Li, Zhichao Wang, Jingzhu Deng, Min Hou, Jia Qiu, Wei Zhao*. TP53-Activated lncRNA GHRLOS Regulates Cell Proliferation, Invasion,and Apoptosis of Non-Small Cell Lung Cancer by Modulating the miR-346/APC Axis.Frontiers in oncology, 11:676202, 2021. (IF: 6.2) (5) Dexin Zhang, Guodong Wang, Ningyi Ma, Ziyang Yuan, Yuqin Dong, Xin Huang, Haishi Qiao#,Ke Ren#. Biomedical Applications of Cell Membrane-Based Biomimetic Nano-Delivery System.Advanced Therapeutics.7(2), 2300304,2023. (IF: 4.6) (6) Hengfei Shi*,Ke Ren*(Co-First), Baojie Lv, Baojie Lv, Wei Zhang, Ying Zhao, Ren Xiang Tan. Erguang Li*. Baicalin from Scutellaria baicalensis blocks respiratory syncytial virus (RSV) infection and reduces inflammatory cell infiltration and lung injury in mice. Scientific Report, 6: 35851, 2016. (IF:5.2) (7) Na Huang*, Wei Guo*,Ke Ren*(Co-First), Yi Jiang, Jian Sun, Wenjing Dai, Wancheng Li, Yi Jiang, Jian Sun, Wenjing Dai, Wei Zhao*. LncRNA AFAP1-AS1 supresses miR-139-5p and promotes cell proliferation and chemotherapy resistance of non-small cell lung cancer by competitively upregulating RRM2.Frontiers in Oncology, 2019.10, 9:1103. (IF=4.8) (8) Wei Guo*,Ke Ren*(Co-First), Ruihong Ning, Caiwu Li, Hemin Zhang, Desheng Li, Lin Xu, Fenghui Sun and Min Dai. Fecal microbiota transplantation provides new insight into wildlife conservation.Global Ecology and Conservation.2020, e01234. (IF:3.8) (9) Xin Huang*,Ke Ren*(Co-First), Zhiyong Chang, Youqing Ye, Dechun Huang*, Wei Zhao, Lixin Yang, Yuqin Dong, Zhiting Cao, Haishi Qiao. Glucose Oxidase and L-Arginine Functionalized Black Phosphorus Nanosheets for Multimodal Targeted Therapy of Glioblastoma.Chemical Engineering Journal. 430(2), 132898, 2022. (IF: 16.7) (10) Youqing Ye*,Ke Ren*(Co-First),Yuqin Dong, Lixin Yang, Dexin Zhang, Ziyang Yuan, Ningyi Ma, Yong Song#, Xin Huang#, and Haishi Qiao#. Mitochondria-Targeting Pyroptosis Amplifier of Lonidamine-Modified Black Phosphorus Nanosheets for Glioblastoma Treatments.ACS Applied Materials & Interfaces. 15, 26285−26297, 2023. (IF: 9.5) (11) Wei Guo*,Ke Ren*(Co-First), Ruihong Ning*, Caiwu Li*, Yu Zhang, Yunong Gan, Xiaoyan Fu, Cenjun Xiao, Yaoyu Pang, Lei Cheng, Siyuan Zhang, Desheng Li, Jiangchao Zhao, Min Dai, Ying Li. Microbial species from multiple maternal body sites shape the developing giant panda (Ailuropoda melanoleuca) cub gut microbiome.Molecular Ecology. 32(9):2271-2286, 2023 (IF:6.7) 3.授权专利 （1）“一种促进单纯疱疹病毒复制的化合物及应用”，2016.10.09，中国，专利号：ZL201610906251.5； （2）“迷迭香酸在制备抑制水痘-带状疱疹病毒的药物中的用途”，2019.10.25， 中国，专利号：ZL201910251925.6； （3）“草果在制备抗病毒药物中的新用途”，201911.07，中国，专利号：ZL201911083128.8； （4）“一种巨噬细胞膜包覆BCG的靶向生物制剂及其应用”，2024，在审； 4.成果奖 （1）“中药防控细菌耐药性的关键技术与应用”四川省科技厅科技进步二等奖2021，参与人； （2）“中药防控多重耐药病原菌传播与感染关键技术创新与应用”，中华医学科技三等奖，2022，参与人； |
