姓名：孟尧

性别：男

1. 代表性科研项目

（1）苦瓜核糖体失活蛋白-单聚乙二醇结合物的结构特性与功能研究（31600269），国家自然科学基金（青年基金），24.0万，国家自然科学基金委员会，2017.01-2019.12，主持

（2）mPEG-ALD定点修饰核糖体失活蛋白MAP30抗肿瘤活性研究（2019YJ0369），四川省科技厅应用基础研究项目，10.0万，四川省科技厅，2019.01-2023.01，主持

（3）一种用于测定核糖体失活蛋白（Ribosome-inactivating proteins, RIP）活性新方法的建立——靛蓝法（S18018），四川省医学科研课题，1.5万，四川省医学会，2018.01-2020.12，主持

（4）基于单PEG化学修饰技术开发药用抗肿瘤苦瓜蛋白MAP30的研究（17ZA0103），四川省教育厅重点项目，2.0万，四川省教育厅，2017.01-2019.12，主持代表性学术论文

2. 代表性学术论文

（1）Di Yang^#, Di Peng^#, Yiping Zhou^#, Zihao Qiang, Li Wan, Xiang Fan, Yanfa Meng, Ge Xu^*, Yao Meng^*. Alpha-Momorcharin, a type I ribosome inactivating protein, induced apoptosis of hepatocellular carcinoma SK-HEP-1 cells through mitochondrial pathway. Nat. Prod. Res. 2023, 21:1-11.

（2）Yiping Zhou^# , Di Yang^#, Zihao Qiang, Yanfa Meng, Ruigang Li, Xiang Fan, Wei Zhao^*, Yao Meng ^*.Ribosome-inactivating protein MAP30 isolated from Momordica charantia L. induces apoptosis in hepatocellular carcinoma cells. Recent Pat Anticancer Drug Discov. 2024, 19(2):223-232.

（3）Kejun Peng^#, Nianhua Deng^#, Yao Meng^#, Qianchuan He, Hao Meng, Ting Luo, Yanru Wei, Yue Kang, Xiaodong Zhou, Fubing Shen*. Alpha-momorcharin inhibits proinflammatory cytokine expression by M1 macrophages but not anti-inflammatory cytokine expression by M2 macrophages. J Inflamm Res. 2022, 15:4853-4872.

（4）Wenkui Sun^#, Jinghui Sun^#, Haowen Zhang, Yanfa Meng, Linli Li, Gangrui Li, Xu Zhang,Yao Meng^*. Chemosynthesis and characterization of site-specific N-terminally PEGylated Α-momorcharin as a potential agent. Scientific Reports. 2018. 8(1): 17729.

（5）Yun Sun, Fenghui Sun, Jianlong Li, Minlu Wu, Xiang Fan, Yanfa Meng, Yao Meng^*.Mono-PEGylation of α-MMC and MAP30 from Momordica charantia L.: Production, Identification and Anti-Tumor Activity. Molecules. 2016. 21(11): 1-9.

（6）Meng Yao^#, Lin Sen^#, Liu Shuang-Feng, Fan Xiang, Li Gang-Rui, Meng Yan-Fa^*. A novel method for simultaneous production of two ribosome-inactivating proteins, α-MMC and MAP30, from Momordica charantia L. PLoS One. 2014, 9(7): e101998.

（7）Meng Yao, Liu Shuang-Feng, Li Juan, Meng Yan-Fa^*, Zhao Xiao-Jun^*. Preparation of an antitumor and antivirus agent: chemical modification of α-MMC and MAP30 from Momordica Charantia L. with covalent conjugation of polyethyelene glycol. Int J Nano Med. 2012, 7: 3133-3142.

（8）Meng Yao^#, Liu Bin^#, Lei Ning, Zheng Jue-Cun, He Qian-Chuan, Li Dan, Zhao Xiao-Jun^*, Shen Fu-Bing^*. Alpha-momorcharin possessing high immunogenicity, immunotoxicity and hepatotoxicity in SD rats. J. Ethnopharmacol. 2012, 139(2): 590-598.

3. 代表性专著

(1). 临床治疗药物监测技术，2012.10第一版，编委

(2). 医学检验科研设计与论文撰写，2022.11第一版，编委

4. 授权专利

(1). 一种测定核糖体失活蛋白活性的方法,专利号ZL201610451601.3,授权日期2019.8.9,第一发明人

(2). 一种新的测定核糖体失活蛋白的酶活性的方法,专利号ZL201910341894.3, 授权日期2019.4.25,第一发明人

(3). 一种同时制备苦瓜α-MMC和MAP30的方法,专利号ZL202011568116.7,授权日期2022.9.2,第一发明人